N, N-dimethylmethanamide is not only a widely used chemical raw material but also an excellent solvent. It is a good solvent for the synthesis of polyvinylnitrile and polyacrylonitrile, such as polyvinylamide, which can be used for the synthesis of many kinds of wet fibers, such as polyvinylamide, etc; For plastic film making; It can also be used as paint remover to remove paint; It can also dissolve some pigments with low solubility and make the pigments have the characteristics of dyes. Dimethylformamide is used for aromatic extraction, separation and recovery of butadiene from C4 fraction and isoprene from C5 fraction. It can also be used as an effective reagent for separation of non hydrocarbon components from paraffin. The solubility of dimethyl terephthalic acid is better than that of m-terephthalic acid, and it can be selectively extracted from dimethyl terephthalic acid or m-terephthalic acid. In petrochemical industry, dimethylformamide can be used as gas absorbent to separate and refine gas. In organic reactions, dimethylformamide is not only widely used as reaction solvent, but also an important intermediate in organic synthesis. It can be used to produce Chlordimeform in pesticide industry; In the pharmaceutical industry, it can be used to synthesize iodamine pyrimidine, doxycycline, cortisone, vitamin B6, iodoside, quzhujing, thiapyrimidine, N-formyl sarcoma lysin, antineoplastic acid, methoxyaromatic mustard, Bian nitrogen mustard, cyclohexylnitrourea, furafluorouracil, hemostatic acid, betamethasone, medroxyprogesterone, cholevita, chlorpheniramine and so on. Dimethylformamide plays a catalytic role in the reactions of hydrogenation, dehydrogenation, dehydration and dehydrohalogenation, which reduces the reaction temperature and improves the purity of the product.
N, N-dimethylmethanamide can be used to purify and remove water. The method is that DMF can be arbitrarily mixed with most organic solvents and water, and has good solubility for organic and inorganic compounds. N. N-dimethylformamide contains a small amount of water. Some decompose during atmospheric distillation to produce dimethylamine and carbon monoxide. Decomposition is accelerated in the presence of acid or base. Therefore, solid potassium hydroxide (sodium hydroxide) is added and partially decomposed after being placed at room temperature for several hours. Barium, magnesium oxide (480 PA), or silica gel (30mm / HPA) is distilled and dried, so the most commonly used molecular sieve is barium sulfate (480 PA), magnesium oxide (30mm / HPA), and then collected. If there is much water, 1 / 10 volume of benzene can be added, and the water and benzene can be evaporated under normal pressure and 80 degree , then dried with anhydrous magnesium sulfate or barium oxide, and finally distilled under reduced pressure. The purified n, N-dimethylformamide should be stored away from light. N. If there is free amine in N-dimethylformamide, it can be checked by the color produced by 2,4 dinitrofluorobenzene.
In addition, it can also be used to titrate solvents in non-aqueous solutions. Solvent for vinyl resin and acetylene. Photometry. The fixed liquid of gas chromatography (the maximum operating temperature is 50 degree , and the solvent is methanol) is used to separate and analyze C2 C5 Hydrocarbons, and can separate n, isobutene, CIS and trans 2 butene. Pesticide residue analysis. Organic synthesis. Peptide synthesis. For photographic industry.
Synthetic n, N-dimethylformamide: 1. Methyl formate is synthesized by carbonylation of carbon monoxide and methanol under high pressure and temperature of 80-100 degree , and then reacts with dimethylamine to produce dimethylformamide. After rectification, the finished product is obtained. 2. The reagent dimethylformamide was purified from industrial product dimethylformamide. If there is a small amount of water in industrial products, it can be removed by 4A molecular sieve. If the moisture content is high, an appropriate amount of granular potassium hydroxide can be added without shaking and fully stand for layering. After separating the water layer containing impurities such as formic acid, add reagent grade benzene with a volume of 1 / 5 of dimethylformamide for atmospheric distillation. When the gas phase temperature reaches 130 degree , add an appropriate amount of phosphorus pentoxide to the residue, cover and oscillate for 3.5H, and filter out the solid after standing, Then dehydrate with potassium hydroxide under the condition of nitrogen filling, and then conduct vacuum distillation under the protection of dry nitrogen to collect the middle fraction to obtain high-purity products.
If you want to know more things about N, N-dimethylmethanamide, please feel free to contact us.